Fig. 3: Morphologic spectrum of cases with TP53 mutations. | Modern Pathology

Fig. 3: Morphologic spectrum of cases with TP53 mutations.

From: Re-evaluating tumors of purported specialized prostatic stromal origin reveals molecular heterogeneity, including non-recurring gene fusions characteristic of uterine and soft tissue sarcoma subtypes

Fig. 3

A Case 4 (PSS) had marked nuclear atypia with multinucleate tumor cells. This case had biallelic inactivation of TP53, an ATRX mutation, and multiple copy number changes. B Case 16 (STUMP) had molecular evidence of biallelic TP53 inactivation. Microscopically, it was a spindle cell lesion with moderate nuclear atypia, inconspicuous mitotic activity, and scattered multinucleate tumor cells. C Case 14 had a TP53 mutation and a TP53 rearrangement involving the first intron of the gene. This was also a spindle cell lesion with mild hypercellularity, moderate nuclear atypia, and scattered multinucleate tumor cells. As seen in these cases, nuclear pleomorphism appears to be common in mesenchymal tumors of the prostate with TP53 aberrations.

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