Table 4 Molecular features.

From: Superficial ALK-rearranged myxoid spindle cell neoplasm: a cutaneous soft tissue tumor with distinctive morphology and immunophenotypic profile

Case

Fusion

ALK partner breakpoint

ALK breakpoint

Hg19 chromosomal RNA contig breakpoints (strand direction)

1

HMBOX1-ALK

NM_024567 exon 5

NM_004304 exon 20

chr8:28837673(+)::chr2:29446394(−)

2

FLNA-ALK

NM_001456 exon 45

chrX:153578017(−)::chr2:29446394(−)

3

MYH10-ALK

NM_005964 exon 33

chr17:8393658(−)::chr2:29446503(−)*

4

MYH10-ALK

NM_005964 intron 26

chr17:8404483(−)::chr2:29446351

5

FLNA-ALK

NM_001456 exon 45

chrX:153578017(−)::chr2:29446394(−)

6

FLNA-ALK

NM_001456 exon 45

chrX:153578017(−)::chr2:29446394(−)

  1. *Breakpoint occurs in intron 19 of ALK, which still includes exon 20 in the fusion product.
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