Fig. 1: Giant cell glioblastoma and glioblastoma with giant cell features.
From: SMARCAL1 loss and alternative lengthening of telomeres (ALT) are enriched in giant cell glioblastoma
Classic giant cell glioblastomas (GC-GBM) were characterized by bizarre pleomorphic cells encompassing the majority of the specimen, had strong p53 positivity, retained ATRX and lacked IDH1 mutations. Glioblastomas with giant cell features (GBM-GC Fx) were characterized by the presence of large pleomorphic cells (arrows), but encompassing only a subset of tumor. A small proportion of tumors with ALT had IDH1 mutations (GBM-GC IDH1). For all panels, original magnification ×400. For the inset highlighting ATRX loss, original magnification ×600.
