Fig. 4: Characteristics of CTNNB1-mutant and APC-mutant testicular Leydig cell tumors (LCTs). | Modern Pathology

Fig. 4: Characteristics of CTNNB1-mutant and APC-mutant testicular Leydig cell tumors (LCTs).

From: Comparative molecular analysis of testicular Leydig cell tumors demonstrates distinct subsets of neoplasms with aggressive histopathologic features

Fig. 4

A Macroscopic appearance of a nonaggressive testicular LCT with an activating CTNNB1 mutation (case 20). The tumor shows a well-circumscribed, smooth, gelatinous, tan cut surface without necrosis or hemorrhage. B Microscopically, case 20 demonstrated minimal cytologic atypia, but mitotic activity was identified (up to 4 mitoses per 10 HPFs). Small pinpoint nucleoli were present. C A significant subpopulation of the cells had cytoplasmic and nuclear expression of B-catenin. D APC-mutant aggressive LCT (case 9). Tumor cells contained variably sized nuclei with vesicular chromatin and prominent nucleoli. E. Nuclear and cytoplasmic β-catenin expression was seen in  a significant subset of the tumor cells (case 9).

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