Fig. 6: β-catenin expression in nonaggressive Leydig cell tumors (LCTs). | Modern Pathology

Fig. 6: β-catenin expression in nonaggressive Leydig cell tumors (LCTs).

From: Comparative molecular analysis of testicular Leydig cell tumors demonstrates distinct subsets of neoplasms with aggressive histopathologic features

Fig. 6

A, B Nonaggressive LCT (1.2 cm) with “foamy” cytoplasm. Nuclear positivity for β-catenin is seen in discrete cell clusters, suggestive of sub-clonal activation of β-catenin. C, D This nonaggressive LCT was 3.5 cm but did not have any additional worrisome features. Note how nuclear β-catenin expression is restricted to the cells on the left side of the micrograph, suggestive of sub-clonal β-catenin activation.

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