Table 3 Immunohistochemical evaluation of nonaggressive Leydig cell tumorsa.

From: Comparative molecular analysis of testicular Leydig cell tumors demonstrates distinct subsets of neoplasms with aggressive histopathologic features

Case

Age

Sizeb

Mitosesc

Β-catd

FH

2SC

1

47

1.1

<1

+

R

–

2

60

0.5

<1

–

R

–

3

45

0.6

<1

–

R

–

4

26

1.8

3

–

R

–

5

25

1.7

<1

+

R

–

6

46

1

1

–

R

–

7

27

1.8

1

+

R

–

8

65

3.2

<1

+

R

–

9

59

3

<1

–

R

–

10

56

1.5

<1

+

R

–

11

79

0.4

<1

–

R

–

12

54

1.2

<1

+

R

–

13

80

0.9

<1

+

R

–

14

28

3.5

<1

+

R

–

15

49

1.1

<1

+

R

–

16

74

2.2

<1

+

R

–

  1. 2SC 2-Succinocysteine, B-cat beta catenin, FH fumarate hydratase, IG Infiltrative growth, IN Ischemic necrosis/infarction, L lost, R retained expression.
  2. aThese cases were originally diagnosed as benign Leydig cell tumor.
  3. bIn centimeters.
  4. cNumber of mitotic figures per 10 high-power fields (40×).
  5. dModerate (2+) to strong (3+) nuclear staining at least focally in ≥5% of cells was considered a positive result.
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