Table 1 Clinico-histopathologic data on de-/trans-differentiated melanoma patients and their tumors.
From: The clinicopathologic spectrum and genomic landscape of de-/trans-differentiated melanoma
Individual | Sample ID | Tissue type | Diagnosis | Age/gender | Site | Conventional melanoma | Heterologous component | Breslow thickness (mm) | Clark level | TILs | TMB (mut/Mb) | Driver genes | Treatment | Recurrence/Metastasis | Follow-up (months) | Patient’s status |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | PD42795a/PR42795a | Conventional melanoma | Dedifferentiated melanoma | 69/M | Left ear | SSM | Dedifferentiated, AFX-like | 5 | V | A | 49.73 | NF1, TP53, BRAF non-p.V600E, CDKN2A, ARID2 | U | U | U | U |
PD42795b/PR42795b | Normal tissue | / | / | |||||||||||||
PD42795c/PR42795c | Dedifferentiated melanoma | 81.62 | NF1, TP53, CDKN2A, ARID2 | |||||||||||||
2 | PD42796a/PR42796a | Conventional melanoma | Heterologous epithelial melanoma | 85/M | Scalp | DM | Epithelial | 20 | V | A | 99.44 | NF1, TP53, BRAF non-p.V600E | WLE and craniectomy | U | 34 | ANED |
PD42796b/PR42796b | Normal tissue | / | / | |||||||||||||
PD42796c/PR42796c | Transdifferentiated melanoma | 97.16 | NF1, TP53, BRAF non-p.V600E | |||||||||||||
3 | PD42797a/PR42797a | Conventional melanoma | Heterologous epithelial melanoma | 76/F | Left upper arm | NM | Epithelial | 12 | V | A | 10.7 | ARID2, NRAS | U | Widespread metastatic disease | 24 | DFD |
PD42797b/PR42797b | Normal tissue | / | / | |||||||||||||
PD42797c/PR42797c | Transdifferentiated melanoma | 10.66 | ARID2, NRAS | |||||||||||||
4 | PD42798c/PR42798c | Dedifferentiated melanoma | Dedifferentiated melanoma | 42/F | Back | NM | Dedifferentiated, AFX-like | 19 | V | NB | 8 | TP53, BRAF p.V600E, CDKN2A, GNAQ | Excision of all nodal metastases Chemotherapy for lung metastasis | Satellite metastasis on the back (diagnosed with the primary melanoma) Bilateral axillary nodal metastasis (diagnosed with the primary melanoma) Possible lung metastasis (diagnosed 3 months after the primary melanoma) Supra-clavicular nodal metastasis (diagnosed 1 year after the primary melanoma) | 34 | ANED |
PD42798b/PR42798b | Normal tissue | / | / | |||||||||||||
PD42798a/PR42798a | In satellite metastasis (dedifferentiated) | 0.62 | GNAQ | |||||||||||||
5 | PD42799a/PR42799a | Dedifferentiated melanoma | Dedifferentiated melanoma | 82/F | Left-arm | LMM | Dedifferentiated, AFX-like | 4.2 | IV | NB | 33.88 | NF1, BRAF non-p.V600E, RAC1 | WLE | U | 25 | ANED |
PD42799b/PR42799b | Normal tissue | / | / | |||||||||||||
6 | PD42800a/PR42800a | Conventional melanoma | Heterologous rhabdomyosarcomatous melanoma | 86/F | Right lower chin | DM | Rhabdomyosarcomatous | 80 | V | NB | 197.08 | NF1, TP53, ATRX, RASA2 | U | No recurrence, no metastasis | 36 | ANED |
PD42800b/PR42800b | Normal tissue | / | / | |||||||||||||
PD42800c/PR42800c | Normal tissue | / | / | |||||||||||||
PD42800d/PR42800d | Transdifferentiated melanoma | 202.46 | NF1, TP53, ATRX, RASA2 | |||||||||||||
7 | PD45890a | Conventional melanoma | Heterologous rhabdomyosarcomatous melanoma | 68/M | Nose | SSM | Rhabdomyosarcomatous | >4 | V | NB | 91.76 | NF1, TP53, CDKN2A, MAP2K1 | WLE | Cervical lymph node metastases (diagnosed with the primary melanoma) Lung metastasis/es (diagnosed 2 months after the primary melanoma) Brain metastasis/es (diagnosed 6 months after the primary melanoma) | 8 | DFD |
PD45890b | Normal tissue | / | / | |||||||||||||
PD45890c | Transdifferentiated melanoma | 119.27 | NF1, TP53, CDKN2A, RAC1 | |||||||||||||
8 | / | Case not sequenced | Dedifferentiated melanoma | 81/M | Vertex scalp | DM | Dedifferentiated, AFX-like | 4.7 | V | A | / | NS | U | U | 0 | U |
9 | / | Case not sequenced | Dedifferentiated melanoma | 75/M | Right lateral neck | DM | Dedifferentiated, AFX-like | 7 | V | NB | / | NS | U | No recurrence, no metastasis | 10 | ANED |
10 | / | Case not sequenced | Dedifferentiated melanoma | 85/M | Anterior scalp | Spindle cell melanoma | Dedifferentiated, AFX-like | 6 | V | NB | / | NS | U | U | 0 | U |
11 | / | Case not sequenced | Dedifferentiated melanoma | 84/F | Right arm | SSM | Dedifferentiated, AFX-like | 7.8 | IV | B | / | NS | U | U | 0 | U |
