Fig. 6: Comparison of the immunophenotypic features between noninvasive breast implant EBV+ LBCL and breast implant ALCL, pathologic stage T2. | Modern Pathology

Fig. 6: Comparison of the immunophenotypic features between noninvasive breast implant EBV+ LBCL and breast implant ALCL, pathologic stage T2.

From: Epstein–Barr-virus-positive large B-cell lymphoma associated with breast implants: an analysis of eight patients suggesting a possible pathogenetic relationship

Fig. 6

A, B Immunohistochemistry with anti-CD20. A Numerous clusters of lymphoma cells display a layering pattern in a cases of breast implant EBV+ large B-cell lymphoma. B The neoplastic cells are negative for CD20, with rare small lymphocytes highlighted in this case of breast implant ALCL. 100×. C, D Immunohistochemistry with anti-CD30. C Layering of lymphoma cells in cases of breast implant EBV+ large B-cell lymphoma. D Apparent cohesiveness of cells above the collagenous capsule in a case of breast implant ALCL; the fibrinoid and necrotic cells at the luminal side appear as unevenly positive. Immunohistochemistry for CD30 with hematoxylin counterstain. 100×. E, F In situ hybridization for EBV-encoded RNA (EBER). E Layers of cells are highlighted with EBER in a case of breast implant EBV+ large B-cell lymphoma. F Neoplastic cells are negative for EBER in cases of breast implant ALCL. EBV-encoded RNA in situ hybridization, 100×.

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