Fig. 6: Photomicrographs of TNBC biopsies. | Modern Pathology

Fig. 6: Photomicrographs of TNBC biopsies.

From: Interobserver variability in the assessment of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative invasive breast carcinoma influences the association with pathological complete response: the IVITA study

Fig. 6

These images illustrate several potential pitfalls which can hamper sTILs assessment, such as DCIS-like TNBC with solid architecture (a–c), an overstained biopsy specimen with folds (d), section artifacts caused by a blunt microtome knife (e), extensive necrosis (f), extensive neutrophilic infiltration in necrotic areas (g), ample crush artifacts (h) and limited amounts of peri- and intra-tumoral stroma (i). Hematoxylin and eosin stainings (a, d-i); SMM-HC immunohistochemistry (b); p63 immunohistochemistry (c).

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