Table 1 Descriptive statistics and associations between TILs and either pCR or RCB class per pathologist.

Rater	TILs versus pCR p value	TILs versus RCB class p value	Mean TILs	Min TILs	Max TILs	Range TILs	Pe25 TILs	Pe50 TILs	Pe75 TILs
P01	0.020^a	0.073	23	0	80	80	5	20	35
P02	0.003^a	0.031	22	0	77	77	5	10	40
P03	0.001^a	0.004^a	24	2	90	88	5.5	10	42.5
P04	0.001^a	0.004^a	42	5	100	95	20	40	70
P05	0.101	0.394	36	2	90	88	7.5	30	60
P06	0.002^a	0.011	35	5	80	75	10	30	55
P07	0.003^a	0.019	43	5	90	85	17.5	40	70
P08	0.003^a	0.006^a	17	0	80	80	2	10	20
P09	0.001^a	0.007^a	29	2	80	78	15	20	40
P10	0.004^a	0.021	20	1	80	79	5	10	30
P11	0.014^a	0.083	31	1	80	79	5	20	30
P12	0.004^a	0.021	29	5	90	85	8	15	50
P13	0.007^a	0.020	31	1	90	89	10	30	40
P14	0.002^a	0.011	17	0	90	90	0	5	40
P15	0.011^a	0.045	30	3	80	77	8	18	55
P16	0.003^a	0.021	44	5	100	95	20	40	75
P17	0.005^a	0.034	38	1	90	89	10	30	65
P18	0.120	0.333	25	4	80	76	15	25	62.5
P19	0.019^a	0.081	27	0	90	90	50	10	45
P20	0.009^a	0.041	25	1	80	79	5	20	45
P21	0.024^a	0.054	26	2	90	88	5	10	30
P22	0.002^a	0.018	26	2	90	88	12.5	25	55
P23	0.013^a	0.016	20	1	70	69	5	17.5	40
P24	0.001^a	0.009	31	5	90	85	10	20	70
P25	0.006^a	0.030	31	2	90	88	10	40	70
P26	0.016^a	0.036	25	0	80	80	5	10	35
P27	0.006^a	0.044	29	5	80	75	5	30	70
P28	0.014^a	0.092	38	1	95	94	1	10	80
P29	0.004^a	0.018	29	2	95	93	10	30	55
P30	0.001^a	0.008^a	23	2	90	88	7.5	15	30
P31	0.013^b	0.055	30	1	90	89	20	30	75
P32	0.002^a	0.006^a	27	0	90	90	10	30	60
P33	0.024^a	0.049	25	0	80	80	5	20	40
P34	0.002^a	0.007^a	30	1	90	89	7.5	20	60
P35	0.159	0.561	28	1	90	89	5	10	35
P36	0.005^a	0.009	20	5	75	70	10	30	50
P37	0.003^a	0.009	32	3	100	97	10	40	75
P38	0.014^a	0.075	35	10	80	70	20	30	50
P39	0.002^a	0.007^a	38	0	100	100	5	10	35
P40	0.001^a	0.009	34	1	90	89	7.5	20	70
Px	0.004^a	0.020	29	5	80	75	9.5	20	50

^aStatistically significant association, with the significance level set at 0.05 (for TILs versus pCR, Mann–Whitney U test) or 0.0083 (for TILs versus RCB class, Kruskal–Wallis test with post hoc Bonferroni correction).
^bInverse statistically significant association, i.e., pCR was associated with lower TILs levels.
Max maximum TILs value, Min minimum TILs value, Pe25 25th percentile, Pe50 50th percentile or median, Pe75 75th percentile, pCR pathological complete response, Range difference between maximum and minimum TILs, TILs tumor-infiltrating lymphocytes.

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