Table 2 Pathological analysis for 24 resected/biopsied specimens.
From: Clinicopathological and genomic features in patients with head and neck neuroendocrine carcinoma
Sample ID | Available tumor specimen | Tumor location | Pathological subtype | Mixture of squamous cell carcinoma component | Ki-67 index | p16 expression | Rb expression | p53 overexpression | RB1 mutation | TP53 mutation |
|---|---|---|---|---|---|---|---|---|---|---|
1 | Biopsy | Paranasal sinus | SCC | No | NA | NA | NA | Pos | Not analyzed | Not analyzed |
2 | Biopsy | Oral | LCNEC | No | 66% | NA | Pos | Pos | Neg | Neg |
3 | Biopsy | Nasal cavity | SCC | No | 81% | NA | Neg | NA | Pos | Pos |
4 | Biopsy | Oropharynx | LCNEC | No | 85% | Pos | Neg | Pos | Pos | Neg |
5 | Biopsy | Nasal cavity | SCC | No | NA | NA | NA | Pos | Not analyzed | Not analyzed |
6 | Biopsy | Paranasal sinus | LCNEC | Yes | 91% | NA | Neg | Pos | Neg | Neg |
7 | Resection | Paranasal sinus | LCNEC | No | NA | NA | NA | Neg | Not analyzed | Not analyzed |
8 | Biopsy | Paranasal sinus | LCNEC | No | 99% | NA | Neg | Pos | Neg | Pos |
9 | Biopsy | Larynx | SCC | No | NA | NA | NA | NA | Not analyzed | Not analyzed |
10 | Biopsy | Hypopharynx | SCC | No | NA | NA | NA | NA | Not analyzed | Not analyzed |
11 | Biopsy | Paranasal sinus | LCNEC | No | 72% | NA | Pos | Pos | Neg | Neg |
12 | Biopsy | Hypopharynx | SCC | No | NA | NA | NA | NA | Not analyzed | Not analyzed |
13 | Biopsy | Paranasal sinus | LCNEC | No | 84% | NA | Neg | Pos | Pos | Pos |
14 | Biopsy | Nasal cavity | SCC | No | 64% | NA | Pos | Pos | Neg | Neg |
15 | Resection | Salivary gland | SCC | No | 59% | NA | Pos | Pos | Neg | Pos |
16 | Biopsy | Nasal cavity | SCC | No | NA | NA | NA | NA | Not analyzed | Not analyzed |
17 | Biopsy | Paranasal sinus | LCNEC | No | NA | NA | Neg | Pos | Not analyzed | Not analyzed |
18 | Resection | Oropharynx | LCNEC | No | 87% | Neg | Pos | Pos | Neg | Neg |
19 | Biopsy | Oropharynx | LCNEC | No | 92% | Pos | Pos | Pos | Neg | Neg |
20 | Biopsy | Oropharynx | LCNEC | No | 93% | Neg | Pos | Pos | Neg | Neg |
21 | Resection | Salivary gland | LCNEC | No | NA | NA | Pos | Pos | Not analyzed | Not analyzed |
22 | Resection | Paranasal sinus | LCNEC | Yes | 96% | NA | Pos | Pos | Neg | Pos |
23 | Biopsy | Oropharynx | SCC | No | NA | Neg | NA | Pos | Not analyzed | Not analyzed |
24 | Resection | Larynx | LCNEC | No | 60% | NA | Pos | Pos | Neg | Pos |
