Fig. 2: Histologic features in intimal sarcomas. | Modern Pathology

Fig. 2: Histologic features in intimal sarcomas.

From: Intimal sarcomas and undifferentiated cardiac sarcomas carry mutually exclusive MDM2, MDM4, and CDK6 amplifications and share a common DNA methylation signature

Fig. 2

Intimal sarcomas often exhibited a loose storiform growth pattern (a). Single cases showed an epithelioid cytomorphology with tumor cells focally forming diffuse sheets and solid areas (b). Some cases showed focal stromal sclerosis, hemosiderin deposits and dystrophic calcifications (c). Case 141642 exhibited a prominent myxoid stroma with elongated, thin-walled vessels and increased perivascular tumor cell density (d). Case 141634 showed variable-sized pseudocystic spaces containing homogeneous eosinophilic material or blood. These spaces are lined by tumor cells. Hemosiderin is present (e). Case 129604 showed a prominent component of aggregating plasma cells (f). Scale bars equal 100 µm.

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