Fig. 4: MDM4 and CDK6 amplifications demonstrated by FISH. | Modern Pathology

Fig. 4: MDM4 and CDK6 amplifications demonstrated by FISH.

From: Intimal sarcomas and undifferentiated cardiac sarcomas carry mutually exclusive MDM2, MDM4, and CDK6 amplifications and share a common DNA methylation signature

Fig. 4

2-color FISH for CDK6 (green signal) or MDM4 (red signal) in MDM2 balanced intimal sarcomas. The upper image (case 163852) shows tight clustered green signals (CDK6) and almost balanced red signals (MDM4). The lower image (case 129602) shows the opposite constellation with abundant red signals (MDM4) and almost balanced green signals (CDK6).

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