Fig. 6: Unsupervised DNA methylation analysis of intimal sarcomas, undifferentiated pleomorphic sarcomas of the left atrium and potential mimics. | Modern Pathology

Fig. 6: Unsupervised DNA methylation analysis of intimal sarcomas, undifferentiated pleomorphic sarcomas of the left atrium and potential mimics.

From: Intimal sarcomas and undifferentiated cardiac sarcomas carry mutually exclusive MDM2, MDM4, and CDK6 amplifications and share a common DNA methylation signature

Fig. 6

Unsupervised t-Distributed Stochastic Neighbor Embedding (t-SNE) analysis of DNA methylation data from intimal sarcomas. The study cohort was compared with methylation data of prototypical soft tissue sarcomas that may histologically or molecularly mimic intimal sarcomas.

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