Table 1 Revised Table 3: Immunohistochemical and molecular genetic findings in seven patients with PTC-DTF and PTC-NFS.

From: Response and correction to correspondence on “CTNBB1 mutations in papillary thyroid carcinoma with prominent myofibroblastic stromal component”

Case

Myofibroblastic Stroma IHC

PTC IHC

Molecular

1

Beta Catenin+ (nuclear)

Keratin AE1/AE3−

MIB1 <5%

PAX8−

P53−

SMA+

Beta Catenin+ (membranous)

Keratin AE1/AE3+

MIB1 <5%

PAX8+

P53−

SMA−

CTNNB1 c.121A>G, (p.Thr41Ala)

2

Beta Catenin+ (nuclear)

Keratin AE1/AE3−

MIB1 <5%

PAX8−

P53−

SMA+

Beta Catenin+ (membranous)

Keratin AE1/AE3+

MIB1 <5%

PAX8+

P53−

SMA−

CTNNB1 c.133T>C, (p.Ser45Pro)

Epithelial component not available for testing, however previously tested13 and positive for BRAF c.1799T>A (p.Val600Glu)

3

Beta Catenin+ (nuclear)

Keratin AE1/AE3−

MIB1 <5%

PAX8−

P53−

SMA+

Beta Catenin+ (membranous)

Keratin AE1/AE3+

MIB1 <5%

PAX8+

P53−

SMA−

CTNNB1 c.121A>G, (p.Thr41Ala)

4

Beta Catenin+ (nuclear)

Keratin AE1/AE3−

MIB1 <5%

PAX8−

P53−

SMA+

Beta Catenin+ (membranous)

Keratin AE1/AE3+

MIB1 <5%

PAX8+

P53−

SMA−

Failed repeat sequencing/QNS,

However, epithelial and mesenchymal component were previously tested and reported positive13 for:

CTNNB1 c.133T>C, (p.Ser45Pro)

BRAF c.1799T>A, (p.Val600Glu)

5

Beta Catenin− (nuclear)

Keratin AE1/AE3−

MIB1 ~5–10%

PAX8−

P53−

SMA+

Beta Catenin+ (membranous)

Keratin AE1/AE3+

MIB1 <5%

PAX8+

P53−

SMA−

BRAF c.1799T>A, (p.Val600Glu)

USP6 rearrangement negative by NGS

6

Tissue exhausted

Tissue exhausted

CTNNB1 c.121A>G, (p.Thr41Ala)

NRAS c.175G>A, (p.Ala59Thr)

7

Beta Catenin+ (nuclear)

Keratin AE1/AE3−

MIB1 <5%

PAX8−

P53−

SMA+

Beta Catenin+ (membranous)

Keratin AE1/AE3+

MIB1 <5%

PAX8+

P53−

SMA−

CTNNB1 c.134C>T, (p.Ser45Phe)

BRAF c.1799T>A, (p.Val600Glu)

  1. NGS next generation sequencing, IHC immunohistochemistry, QNS quantity not sufficient.
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