Fig. 6: Schematic representation of the most important clinical-, morphological features and signaling pathways characterizing the “self-limited” nature of NF. | Modern Pathology

Fig. 6: Schematic representation of the most important clinical-, morphological features and signaling pathways characterizing the “self-limited” nature of NF.

From: Nodular fasciitis: a comprehensive, time-correlated investigation of 17 cases

Fig. 6

Over time, NF displays a decrease in size (dark blue) and cellularity (pale blue). The number of the USP6 split signal harboring cells (red) and the expression of anti-apoptotic markers (TRAIL nuclear immunohistochemistry, green) also decrease, while the proapoptotic signals (TRAIL membrane immunohistochemistry, dotted-green) and senescence-related p27 and p16 expression (yellow) increase.

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