Fig. 4: Consensus analytic response curves of FDA-cleared PD-L1 assays.
From: Quantitative comparison of PD-L1 IHC assays against NIST standard reference material 1934
In each panel, the stain intensity (y axis) is expressed as a percentage of the maximum stain intensity for each assay and graphed as a function of PD-L1 concentration (x axis). A Performance characteristics of the VENTANA SP263 and SP142 PD-L1 assays, correlating the generation of a visible signal at various PD-L1 concentrations. Each dot is the mean ± SD of the pool of laboratories participating in the survey. B Performance characteristics of the PharmDx 28-8 and 22C3 PD-L1 assays. For comparison, the analytic response curves shown in panel A are included.
