Table 1 VISTA expression and its association with the clinicopathologic parameters of patients with endometrial cancer.
Parameters | N | VISTA in ICs | P-value | VISTA in TCs | P-value | ||
|---|---|---|---|---|---|---|---|
Negative N | Positive N (%) | Negative N | Positive N (%) | ||||
Age (N = 839) | 0.308 | 0.003 | |||||
<58 years | 412 | 90 | 322 (78.2) | 395 | 17 (4.1) | ||
≥58 years | 427 | 106 | 321 (75.2) | 387 | 40 (9.4) | ||
FIGO stage (N = 804) | 0.001 | 0.695 | |||||
I | 546 | 118 | 428 (78.4) | 512 | 34 (6.2) | ||
II | 39 | 4 | 35 (89.7) | 35 | 4 (10.3) | ||
III | 174 | 42 | 132 (75.9) | 161 | 13 (7.5) | ||
IV | 45 | 20 | 25 (55.6) | 43 | 2 (4.4) | ||
Tumor grade (N = 839) | 0.10 | 0.121 | |||||
Low | 407 | 85 | 322 (79.1) | 385 | 22 (5.4) | ||
High | 432 | 111 | 321 (74.3) | 397 | 35 (8.1) | ||
Histology (N = 839) | 0.071 | <0.001 | |||||
Endometrioid | 596 | 130 | 466 (78.2) | 567 | 28 (4.7) | ||
Serous | 114 | 27 | 87 (76.3) | 105 | 9 (7.9) | ||
Clear cell | 47 | 10 | 37 (78.7) | 33 | 14 (29.8) | ||
Carcinosarcoma | 54 | 21 | 33 (61.1) | 49 | 5 (9.2) | ||
Others | 28 | 8 | 20 (71.4) | 27 | 1 (3.5) | ||
Myometrial invasion (N = 809) | 0.112 | 0.477 | |||||
<1/2 | 588 | 126 | 462 (78.6) | 551 | 37 (6.3) | ||
≥1/2 | 221 | 59 | 162 (73.3) | 204 | 17 (7.7) | ||
LVSI (N = 813) | 0.561 | 0.257 | |||||
Absent | 585 | 132 | 453 (77.4) | 542 | 43 (7.4) | ||
Present | 233 | 57 | 176 (75.5) | 221 | 12 (5.2) | ||
Mismatch repair (N = 829) | <0.001 | 0.437 | |||||
Proficient | 615 | 166 | 449 (73.0) | 571 | 44 (7.2) | ||
Deficient | 214 | 27 | 187 (87.4) | 202 | 12 (5.6) | ||
Molecular subgroup (N = 598) | <0.001 | 0.50 | |||||
POLEmut | 51 | 5 | 46 (90.2) | 49 | 2 (3.9) | ||
MMRd | 163 | 23 | 140 (85.9) | 153 | 10 (6.1) | ||
NSMP | 246 | 68 | 178 (72.4) | 232 | 17 (6.8) | ||
p53mut | 132 | 44 | 88 (66.7) | 122 | 13 (9.6) | ||
PD-L1 (N = 833) | <0.001 | 0.304 | |||||
Negative | 457 | 156 | 301 (65.9) | 422 | 35 (7.7) | ||
Positive | 376 | 39 | 337 (89.6) | 354 | 22 (5.9) | ||
Density of CD8+ T cell (N = 837) | <0.001 | 0.928 | |||||
Low | 416 | 127 | 289 (69.4) | 388 | 28 (6.7) | ||
High | 421 | 68 | 353 (83.8) | 392 | 29 (6.9) | ||
