Table 2 Heterogeneity of PD-L1 expression, lymphocytes infiltration and immune-to-tumor cell distances between primary and metastatic samples in non-small cell lung cancer.

From: Heterogeneity of programmed death-ligand 1 expression and infiltrating lymphocytes in paired resected primary and metastatic non-small cell lung cancer

Immune markers

Heterogeneity

Paired

Non-paired

 

PT

MT

pa

pb

TPS (average, score %)

35.91%

42.34%

0.046*

0.096

PD-L1+ (average, cell/mm2)

859.63

1391.86

0.029*

0.042*

CD8+ (average, cell/mm2)

736.90

436.75

0.040*

0.022*

CD68+ (average, cell/mm2)

776.18

592.01

0.068

0.102

CD8+ to TCs (average, μm)

55.24

80.26

0.038*

0.304

CD68+ to TCs (average, μm)

41.62

46.68

0.285

0.507

  1. aWilcoxon signed-rank test.
  2. bMann–Whitney test; *p < 0.05, considered statistically significant. PT primary tumor, MT metastatic tumor, TPS tumor proportion score, TCs tumor cells.
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