Fig. 2: Identification of unusual MMR-D tumors after IHC and MSI review: *11/13 cases were clearly assigned to one category of loss of MMR proteins and 2/11 cases remained indeterminate for at least one MMR protein (PMS2). | Modern Pathology

Fig. 2: Identification of unusual MMR-D tumors after IHC and MSI review: *11/13 cases were clearly assigned to one category of loss of MMR proteins and 2/11 cases remained indeterminate for at least one MMR protein (PMS2).

From: An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes

Fig. 2

**: for one case, initial IHC was performed on biopsy with normal expression of MMR proteins but with an isolated loss of PMS2 on the surgical sample, and for the other case, initial IHC was performed on a polyp with normal expression of MMR protein but with PMS2/MLH1 loss on invasive carcinoma.

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