Fig. 6: NGS analysis. | Modern Pathology

Fig. 6: NGS analysis.

From: An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes

Fig. 6

Tumor mutational burden (TMB) is reported as mutations per megabase (mut/Mb) in the y-axis. Tumor types are indicated on the x-axis. The TMB value is mentioned above each graph bar. Tumors were divided into three categories according to TMB value: TMB-high: ≥20 mut/Mb, TMB-intermediate: between 6 and 19 mut/Mb and TMB-low: ≤5 mut/Mb. Even after excluding the only ultra-mutated tumor (501 mut/Mb) corresponding to LS associated with a somatic PolD1 mutation, the range of TMB values was highly variable, ranging from 4 to 145 mut/Mb. All cases, except for four cases, were MSI by NGS analysis. Stars above the graph bars indicate MSS (microsatellite stable) tumors; yellow stars represent MSS tumors both with NGS and MSI-PCR and brown stars indicate MSS tumors with NGS but MSI-H with MSI-PCR.

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