Fig. 3: Stromal changes associated with invasion.
From: Updates in grading and invasion assessment in lung adenocarcinoma
A While an acinar pattern is a tumor cell pattern of invasion, the presence of desmoplasia (asterisk) is also a key observation. B While vessels can become hyalinized, vascular invasion when recognized is proof of invasion. C Pleural reaction can be seen without pleural invasion, but (D) elastin stain can help delineate the edge of the pleura, with glands outside that edge. E Needle tracts are linear are while fibroblastic (arrowheads), can be distinguished from desmoplasia. F Needle tracts can also be recognized as spaces (arrowhead) in the tissue with histiocytic reaction seen in (G) at arrows.
