Fig. 7: Adenocarcinoma features in the consideration of invasion.
From: Updates in grading and invasion assessment in lung adenocarcinoma
A Invasive mucinous adenocarcinoma is characterized by growth along pre-existing alveoli, but back to back glands and stromal reaction should be considered invasive as seen in (B). C While many tumors have an apical mucin droplet resembling gastric mucosa, some have a more goblet cell morphology. D While not associated with stromal reaction, nests of tumor cells away from the main mass and showing histologic features of the invasive tumor pattern are a form of invasion known as spread through air spaces, but does not add to invasive size.
