Fig. 1: Tumor budding and cell cluster size in EAC. | Modern Pathology

Fig. 1: Tumor budding and cell cluster size in EAC.

From: Grading of endocervical adenocarcinoma: a novel prognostic system based on tumor budding and cell cluster size

Fig. 1

Tumor budding (A–C): overview (A × 50) and details (B × 200) of an EAC with high tumor budding activity, indicated by the branching of numerous small tumor clusters of <5 cells into the surrounding tissue; details of low tumor budding activity with 2 clusters of tumor cells, each showing budding (arrows) into the tumor stroma (C × 200). Cell nest size (D–F): single cell invasion (D × 200), intermediate (E × 200) and large (F × 200) sized cell clusters.

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