Table 1 Algorithm for determining novel grading system based upon tumor budding and cell cluster size in EAC*.

  0

1

  <15

2

 ≧15

3

 >15 cells or pure glands (no clusters)

1

  5–15 cells

2

  2–4 cells

3

  Single cell

4

Grading

Total score

  G1 (well differentiated)

2–3

  G2 (moderately differentiated)

4–5

  G3 (poorly differentiated)

6–7