Table 2 Association of tumor budding, cell cluster size, novel grade, and FIGO grade with clinicopathological parameters in EAC*.

	Tumor budding score			p	Tumor cell cluster size score				p	Novel grade			P	FIGO grade			p
	1 n = 264	2 n = 52	3 n = 82	p	1 n = 217	2 n = 47	3, n = 48	4 n = 86	p	G1 n = 264	G2 n = 28	G3 n = 106	P	G1 n = 291	G2 n = 59	G3 n = 48	p
Age				0.165				0.451					0.323				0.857
≤46 yr	154	28	37		127	27	24	41		154	14	51		162	32	25
>46 yr	110	24	45		90	20	24	45		110	14	55		129	27	23
WHO type				<0.001					<0.001				<0.001				0.554
HPVA	220	38	36		180	40	36	38		220	22	52		220	40	34
HPVI	32	14	42		29	3	12	44		32	6	50		71	10	7
Silva pattern**				<0.001					<0.001				<0.001				<0.001
A	58	0	0		58	0	0	0		58	0	0		56	2	0
B	43	3	0		43	0	3	0		43	3	0		45	1	0
C	127	30	33		83	44	27	36		127	14	49		119	39	32
Lymph node metastasis				<0.001					<0.001				<0.001				0.076
Yes	15	7	32		8	7	9	30		15	3	36		31	15	8
No	208	41	43		170	38	38	46		208	24	60		210	44	38
Ovarian involvement				<0.001					0.002				0.001				0.56
Yes	2	2	8		2	0	2	8		2	2	8		10	2	0
No	241	49	71		197	44	45	75		241	25	95		259	57	45
Lymphovascular invasion (LVI)				<0.001					<0.001				<0.001				0.024
Yes	56	33	76		30	26	33	76		56	15	94		109	33	23
No	208	19	6		187	21	15	10		208	13	12		182	26	25
Perineural involvement (PNI)				<0.001					<0.001				<0.001				0.516
Yes	1	7	21		0	1	6	22		1	4	24		21	6	2
No	263	45	61		217	46	42	64		263	24	82		270	53	46
Depth of invasion of cervical wall				<0.001					<0.001				<0.001				0.001
≤1/3	76	2	0		72	4	2	0		76	2	0		69	6	3
>1/3, ≤2/3	122	12	16		108	14	9	19		121	5	24		110	20	20
å 2/3	65	37	64		36	29	37	64		65	22	79		108	33	25
FIGO stage				<0.001					<0.001				<0.001				0.155
I	236	38	33		201	35	30	41		236	20	51		230	43	34
II–IV	25	14	48		13	12	18	44		25	8	54		57	16	14
Aberrant p53 expression				<0.001					<0.001				<0.001				0.162
Yes	12	8	28		11	1	5	31		12	3	33		37	9	2
No	213	42	54		174	39	41	55		213	23	73		216	48	45

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