Table 3 Association of tumor budding, cell cluster size, novel grade, and FIGO grade with overall survival and tumor recurrence in EAC (univariate analysis)*.

From: Grading of endocervical adenocarcinoma: a novel prognostic system based on tumor budding and cell cluster size

Total

Overall survival (OS)

Tumor recurrence

Events

Mean ± SD (mo.)

P

Events

Mean ± SD (mo.)

P

Tumor budding score

<0.001

  

<0.001

1

228

4

176.0 ± 5.2

8

171.4 ± 5.7

2

46

3

144.8 ± 5.7

5

135.8 ± 8.2

3

63

13

119.6 ± 12.6

18

110.3 ± 11.7

Cell cluster size score

<0.001

  

<0.001

1

188

2

174.3 ± 7.5

6

168.5 ± 8.0

2

40

2

162.1 ± 6.8

2

162.6 ± 6.5

3

43

3

125.3 ± 8.8

4

121.4 ± 9.5

4

66

13

113.9 ± 14.6

19

102.8 ± 13.2

Novel grade

<0.001

  

<0.001

G1

227

4

176.0 ± 5.2

8

171.3 ± 5.7

G2

27

1

134.9 ± 5.0

1

134.9 ± 5.1

G3

83

15

122.9 ± 11.5

22

111.7 ± 10.7

FIGO grade

0.568

  

0.420

G1

254

13

170.3 ± 4.3

21

163.3 ± 4.8

G2

45

3

162.3 ± 8.8

3

161.4 ± 9.4

G3

43

4

135.8 ± 6.5

6

126.5 ± 8.5

  1. *Annotation: The algorithm for novel grade and related scores is given Table 1.
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