Table 5 Genetic findings and biomarkers with potential relevance in the work-up of HSTCL.

Biomarker	Test	Purpose	Disease	Comment
i(7q)	FISH	Diagnosis	HSTCL	FISH is more sensitive than karyotyping
SETD2 mutations^a,¹⁰⁰	NGS	Diagnosis	HSTCL	Could help in the diagnosis
STAT5B mutations^a,^100,106	NGS	Diagnosis	HSTCL	Potentially targetable
STAT3 mutations^a,^100,106	NGS	Diagnosis	HSTCL	Potentially targetable

SETD2 SET domain containing 2, histone lysine methyltransferase, STAT3 signal transducer and activator of transcription 3.
^aNon-specific; they are seen in other T-cell lymphomas but in the right clinical setting could support the diagnosis of HSTCL.

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