Table 7 Genetic findings and biomarkers with potential relevance in the work-up of ATLL.

From: Genetic profiling and biomarkers in peripheral T-cell lymphomas: current role in the diagnostic work-up

Biomarker

Test

Purpose

Disease

Comment

PLCG1 mutations126

NGS

Treatment

ATLL

Clinical interest in developing PLCγ1i

CCR4 mutations136

NGS

Prognosis

ATLL

Associated with skin involvement and adverse prognosis

CCR4 expression136,137

IHC

Treatment

ATLL

Predicts better responses to mogamulizumab

IRF4 expression126,133,134

IHC

Prognosis

ATLL

Adverse prognosis and poor responses to therapy

TP53 mutations

NGS

Prognosis

ATLL

Adverse prognosis

  1. ATLL adult T cell leukemia/lymphoma, PLCG1 phospholipase C gamma 1, CCR4 C-C Motif Chemokine Receptor 4, IRF4 interferon regulatory factor 4.
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