Table 2 Genes that finally selected in building the molecular classifier.

From: A novel diagnostic approach for the classification of small B-cell lymphoid neoplasms based on the NanoString platform

Classification

Differentially expressed genes

CLL/SLL

BTLA, ARHGAP44, ZBTB24, CLNK, CD200

cMCL

SOX11, PLEKHG4B, ZNF711, CCND1a, FAM129C, ABCA6

FL

BCL2, EML6, ELL3, CTLA4, FCER2, IGF2BP3, RGS13, EBF1

nnMCL

CCND1a, ZNF331, PAX5, CNR1

MZL

FCRLA, HDAC9, MS4A1, SIGLEC6, ZBTB32, BHLHE41

LPL/WM

CCR2, HOPX, FKBP11, ANK3, ZNF226, MFAP5, MEF2A

Additional markers

FL

IGH-BCL2 translocation or t(14;18)(q32;q21)

LPL/WM

MYD88 L265P mutation

HCL

BRAF V600E mutation

  1. CLL/SLL chronic lymphocytic leukemia/small lymphocytic lymphoma, cMCL conventional mantle cell lymphoma, nnMCL leukemic non-nodal mantle cell lymphoma, FL follicular lymphoma, MZL marginal zone lymphoma, LPL/WM lymphoplasmacytic lymphoma/Waldenström’s macroglobulinemia, HCL hairy-cell leukemia.
  2. aCCND1 gene was selected as marker in both cMCL and nnMCL.
Back to article page