Fig. 4: Nonlinear microscopy (NLM) images of Gleason pattern 3 prostatic adenocarcinoma with small glands in prostate needle core biopsies. | Modern Pathology

Fig. 4: Nonlinear microscopy (NLM) images of Gleason pattern 3 prostatic adenocarcinoma with small glands in prostate needle core biopsies.

From: Real-time diagnosis and Gleason grading of prostate core needle biopsies using nonlinear microscopy

Fig. 4

Interpretation of such areas can be problematic and can appear to be merging into pattern 4. A Small discrete glands (NLM: top, formalin-fixed paraffin-embedded (FFPE) H&E: bottom). B Malignant glands infiltrating the prostatic stroma between benign glands (NLM: top, formalin-fixed paraffin-embedded (FFPE) H&E: bottom). Basal and secretory cell layers are seen in the benign glands in the NLM image and FFPE H&E section. Scale bars = 50 µm.

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