Fig. 4: Comparative analyses of NETs and NECs.
From: Clinical and genomic analyses of neuroendocrine neoplasms of the breast
A, B Comparison of the baseline characteristics between NETs and NECs. C, D Landscape of frequency mutated genes in NETs and NECs. E, F Comparative analyses of 7 pathways between NETs and NECs. Comparative analysis of NETs and NECs showed that Ki67 expression in NECs was significantly higher than that in NETs. ACE (33.3%, 2/6) was the most frequently mutated gene in the NETs, while KMT2C (18.2%, 2/11) was the most frequently mutated gene in the NECs. The oncogenic/likely oncogenic mutations of NETs in PI3K pathway genes (P < 0.001) and MAPK signaling pathway genes (P = 0.035) affected higher proportions than those of NECs. *P < 0.05, Fisher’s exact test. The X-axis is the sample type, and the Y-axis is the percentage of NENs with genetic mutations in each genetic pathway.
