Fig. 2: Associations of LAG-3 expression with clinicopathologic and molecular features in primary lung squamous-cell carcinomas. | Modern Pathology

Fig. 2: Associations of LAG-3 expression with clinicopathologic and molecular features in primary lung squamous-cell carcinomas.

From: Lymphocyte-activation gene 3 in non-small-cell lung carcinomas: correlations with clinicopathologic features and prognostic significance

Fig. 2

A Representative images of LAG-3 and CD8 immunohistochemical staining in well-differentiated (top row) and poorly-differentiated (bottom row) squamous cell carcinomas. H&E: hematoxylin and eosin. B LAG-3 (left), CD8 (middle), and LAG-3/CD8 index (right) stratified by clinicopathologic and molecular features. Diamonds and bars represent medians and interquartile ranges, respectively. Vertical dotted lines indicate medians of the cohort. Open diamonds indicate p < 0.05 (Wilcoxon rank-sum tests). C Multivariate logistic regression analysis. Diamonds and bars represent odds ratios and 95% confidence intervals, respectively. Open diamonds indicate p < 0.05 (logistic regression analysis). W well-differentiated, M moderately differentiated, P poorly-differentiated, Pleural inv. pleural invasion, LVI lymphovascular invasion.

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