Table 2 Histopathologic and immunohistochemical features of testicular adult granulosa cell tumors.
CASE | CYTOMORPHOLOGY | ARCHITECTURE | MITOSESa | CELL. | PLEOM. | NECR. | INF. GROWTH | +IHC | − IHC |
|---|---|---|---|---|---|---|---|---|---|
1 | Epithelioid, spindled | Nested, solid | 3 | High | Minimal | No | No | Inhibin, SF1, WT-1 | EMA, OCT3/4, B-catenin |
2 | Epithelioid, spindled | Nested, solid | 3 | High | Minimal | No | Entrapped tubules | Inhibin, AE1/AE3 (focal) | SALL4 |
3 | Epithelioid, spindled | Nested, fascicular | 2 | Moderate-to-high | Minimal | No | Entrapped tubules | Inhibin, WT-1, Calretinin | OCT3/4 |
4 | Epithelioid | Nested, trabecular, corded | 8 | High | Minimal | No | No | ||
5 | Epithelioid, spindled | Nested, corded, tubular, fascicular, solid | 6 | High | Minimal | No | No | Inhibin, WT-1 | SALL4, SF1, Calretinin, B-catenin |
6 | Epithelioid, spindled | Solid | 17 | High | Minimal | No | Entrapped tubules | N/A | N/A |
7 | Epithelioid | Nested | <1 | High | Minimal | No | No | Inhibin, WT-1, Calretinin | CK, EMA, CD45, S100, HMB45, Desmin, Myogenin, MyoD1, SMA, PLAP, CD30, CD117 |
8 | Epithelioid | Nested, solid, trabecular, corded | <1 | High | Minimal | No | No | SMA | CK, EMA, Desmin, LCA, S100 |
9 | Epithelioid, spindled | Nested, solid, reticular (in myxoid stroma) | 3 | Moderate (in myxoid areas), focally high | Minimal | No | Infiltrates rete testis | N/A | N/A |
10 | Epithelioid, spindled | Solid (in myxoid stroma) | 13 | High | Minimal | No | No | N/A | N/A |
11 | Epithelioid, spindled | Nested, solid, fascicular | 7 | High | Minimal-to-moderate | No | Infiltrates soft tissue | N/A | N/A |
12 | Spindled | Solid, fascicular | 22 | High | Minimal-to-moderate | No | No | Inhibin, SF1, Calretinin, SMA | SALL4, CK, S100, Desmin, CD34, Bcl-2, CD31, P63 |
13 | Epithelioid | Nested | 107 | High | Moderate-to-severe (focally) | Yes | Infiltrates testicular parenchyma | Inhibin, SF1, WT-1 | SALL4, OCT3/4, B-catenin |
