Fig. 2: Functional characterization of the differentially expressed proteins in Wilson disease using DAVID resource. | Modern Pathology

Fig. 2: Functional characterization of the differentially expressed proteins in Wilson disease using DAVID resource.

From: Metallothionein immunohistochemistry has high sensitivity and specificity for detection of Wilson disease

Fig. 2

A Biological processes enriched among the overexpressed proteins in Wilson disease (FDR value < 0.05). B Protein-protein interaction network of the overexpressed proteins involved in immune response C Biological processes enriched among the under-expressed proteins in Wilson disease (FDR value < 0.05). D Protein-protein interaction network of the under-expressed proteins involved in oxidation-reduction process. Protein-protein interaction networks were generated using String database and analyzed in Cytoscape. Node color gradient is based on the fold-change of the over-expressed and under-expressed proteins. The width of the edge indicates the confidence of the interaction. The confidence ranges from 0.4 (low confidence) to 0.9 (high confidence) given by the String database.

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