Table 2 Pathologic characteristics and metallothionein immunohistochemical staining results for patients with Wilson disease.
Case # | Diagnosis | Specimen type | Stage | Histologic pattern | Copper stain | Metallothionein immunohistochemistry | ||||
|---|---|---|---|---|---|---|---|---|---|---|
No staining (0) | Mild Intensity (1+) | Moderate intensity (2+) | Strong intensity (3+) | H-score | ||||||
1 | Wilson | Resection | 4 | Established cirrhosis | Mild, focal | 0% | 0% | 10% | 90% | 290 |
2 | Wilson | Resection | 4 | Fulminant hepatic failure with mild steatosis | Mild, focal | 0% | 0% | 10% | 90% | 290 |
3 | Wilson | Resection | 4 | Established cirrhosis | Mild, diffuse | 0% | 0% | 40% | 60% | 260 |
4 | Wilson | Resection | 1 | Submassive hepatic necrosis with nodular regeneration | NA | 0% | 0% | 80% | 20% | 220 |
5 | Wilson | Resection | 4 | Severe active hepatitis, moderate steatosis, prominent cholestasis | Negative | 0% | 0% | 10% | 90% | 290 |
6 | Wilson | Resection | 4 | Cirrhosis with cholestasis | Negative | 0% | 20% | 30% | 50% | 230 |
7 | Wilson | Resection | 4 | Cirrhosis with cholestasis | NA | 0% | 0% | 60% | 40% | 240 |
8 | Wilson | Resection | 4 | Established cirrhosis | NA | 0% | 0% | 0% | 100% | 300 |
9 | Wilson | Biopsy | 2 | Steatohepatitis | Moderate | 0% | 0% | 0% | 100% | 300 |
10 | Wilson | Biopsy | 2 | Hepatitis and steatohepatitis | Negative | 0% | 0% | 20% | 80% | 280 |
11 | Wilson | Biopsy | 0 | Steatohepatitis | NA | 0% | 0% | 0% | 100% | 300 |
12 | Wilson | Biopsy | 2 | Steatohepatitis | NA | 0% | 0% | 0% | 100% | 300 |
13 | Wilson | Resection | 4 | Steatohepatitis, necrosis, and cirrhosis | Negative | 0% | 0% | 30% | 70% | 270 |
14 | Wilson | Biopsy | 0 | Steatosis | NA | 0% | 10% | 60% | 30% | 220 |
15 | Wilson | Biopsy | 2 | Mild portal hepatitis with ductular reaction | Mild, focal | 0% | 10% | 0% | 90% | 280 |
16 | Wilson | Resection | 4 | Established cirrhosis | NA | 20% | 30% | 0% | 50% | 180 |
17 | Wilson | Biopsy | 1 | Severe active hepatitis, mild steatosis, prominent cholestasis | Mild, focal | 0% | 10% | 60% | 30% | 220 |
18 | Wilson | Resection | 4 | Cholestatic cirrhosis | NA | 0% | 0% | 70% | 30% | 230 |
19 | Wilson | Resection | 4 | Established cirrhosis | NA | 0% | 0% | 70% | 30% | 230 |
20 | Wilson | Biopsy | 1 | Mild portal and lobular hepatitis with mild steatosis | Negative | 0% | 0% | 10% | 90% | 290 |
