Table 4 Extent and intensity of metallothionein immunohistochemistry by diagnosis.

From: Metallothionein immunohistochemistry has high sensitivity and specificity for detection of Wilson disease

Diagnosis

N

Cases with any MT staining

Cases with >50% of hepatocytes staining (any intensity)

Cases with at least moderate MT staining in >50% of hepatocytes

Cases with strong intensity staining in >33% of hepatocytes

Wilson disease

20

20 (100%)

20 (100%)

20 (100%)

15 (75%)

All control cases

203

75 (37%)

18 (9%)

0 (0%)

0 (0%)

   Normal liver

20

8 (40%)

0 (0%)

0 (0%)

0 (0%)

   Autoimmune hepatitis

50

22 (44%)

5 (10%)

0 (0%)

0 (0%)

   Chronic biliary tract disease

42

22 (52%)

8 (19%)

0 (0%)

0 (0%)

   Steatohepatitis

51

10 (20%)

1 (2%)

0 (0%)

0 (0%)

   Chronic hepatitis C

40

13 (33%)

4 (10%)

0 (0%)

0 (0%)