Fig. 3: Genetic profiles.

A Heatmap visualizing the TMB value as mutations per megabase. B Heatmap visualizing the MSI score as the ratio between unstable and stable loci. C Summary of genetic alterations (SNVs and InDels) of known clinical relevance detected in each tumour. Red = alteration. D Heatmap visualizing CNVs in the genes with genetic alterations showed in C, Grey = normal copy number, red = gains, blue = loss. Black diamond = tumour suppressor gene.