Fig. 4: 3D nuclear characteristics of the non-tumor cells of different NLPHL patterns and THRLBCL.

A Surfaces of the DAPI-stained T cell nuclei of NLPHL patterns (A, C, and E) and THRLBCL. B Volumes of the DAPI-stained T cell nuclei are significantly enlarged in THRLBCL when compared with NLPHL patterns A and C (**p < 0.01, Kruskal–Wallis test with Dunn’s post hoc test for multiple comparisons). NLPHL pattern E T cells show a broad spectrum of volumes. C Surfaces of the OCT2-stained reactive B cell nuclei of NLPHL patterns (A, C, and E) and THRLBCL. D Volumes of the OCT2-stained reactive B cell nuclei of NLPHL patterns (A, C, and E) and THRLBCL.