Fig. 1: Morphologic variants and p16 expression in PEIN. | Modern Pathology

Fig. 1: Morphologic variants and p16 expression in PEIN.

From: Pathological characterization and clinical outcome of penile intraepithelial neoplasia variants: a North American series

Fig. 1

A, B Penile intraepithelial neoplasia (PeIN), basaloid variant, characterized by full-thickness small, immature basaloid cells. P16 immunostain shows full-thickness positivity by immunohistochemistry (Magnification, X200). C, D PeIN, warty variant. There is hyperparakeratosis and koilocytosis. P16 stain is positive. HR-HPV 16 and HPV73 were positive in this case (Magnification, X200). E, F Differentiated PeIN with hyperkeratosis and parakeratosis, acanthosis, and basal atypia. p16 stain and HPV were negative. Lichen sclerosus with homogenization of the subepithelial collagen band is present in the right side of the image (Magnification, X200).

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