Fig. 3: Morphologic variants and p16 expression in PEIN. | Modern Pathology

Fig. 3: Morphologic variants and p16 expression in PEIN.

From: Pathological characterization and clinical outcome of penile intraepithelial neoplasia variants: a North American series

Fig. 3

A PeIN, hybrid warty-basaloid and basaloid (Magnification, X100). B Detail of the surface warty features. C Detail of the lower layer basaloid features. D P16 positivity by immunohistochemistry is predominantly full thickness with sparing of the upper keratinizing layer. E Basaloid PeIN was also present in this lesion, continuous with the warty-basaloid area. F P16 expression in the lower two-thirds of the epithelium. This lesion was HR-HPV16 and 18 positive (Magnification, X200).

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