Fig. 4: Representative case of PTCL-GATA3 subtype (DL52, A–H). | Modern Pathology

Fig. 4: Representative case of PTCL-GATA3 subtype (DL52, A–H).

From: Nodal cytotoxic peripheral T-cell lymphoma occurs frequently in the clinical setting of immunodysregulation and is associated with recurrent epigenetic alterations

Fig. 4

A On H&E section, the lymph node showed atypical lymphoid infiltrate composed of large cells with vesicular nuclei and conspicuous nucleoli. Scattered eosinophils are associated. The neoplastic cells were positive for CD3 (B), CD4 (C), CD8 (D), and showed loss of CD5 (E). They strongly expressed granzyme B (F) and showed nuclear positivity for GATA3 (G) with negativity for TBX21 (H). Stains original magnification, ×400, H&E hematoxylin and eosin.

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