Fig. 2: Histopathological and SNP array findings in a DPN (Case 6). | Modern Pathology

Fig. 2: Histopathological and SNP array findings in a DPN (Case 6).

From: Towards diagnostic criteria for malignant deep penetrating melanocytic tumors using single nucleotide polymorphism array and next-generation sequencing

Fig. 2

A Skin excision from the lower back of a 33-year-old man with an asymmetrical, compound melanocytic lesion, measuring 10 mm, with a DPN on the left and an unrelated nevus on the right. B The DPN component is wedge-shaped and shows a nested growth of slightly pigmented melanocytes with heavily pigmented melanophages in between. C The common nevus shows a nested growth of small ‘nevoid’ melanocytes. D BRAF V600E staining is positive in the common nevus on the right and is negative in the DPN on the left. E β-catenin staining shows strong cytoplasmatic and nuclear staining in the DPN. F SNP   array showed a single gain of 7p13.3 with the CHN2 gene segment. This case did not show any signs of malignancy. NGS of the DPN showed CTNNB1D32N and MAP2K1P105_I107delinsL mutations.

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