Table 1 Clinical characteristics of a cohort of 20 deep penetrating tumors.

Case	Initial differential diagnosis	Sex	Age	Location	Management	Follow-up	SNB	Outcome	Final diagnosis
1	DPN, blue nevus, or melanoma	M	29	Shoulder	Re-excision	10 months	NP	NED	DPN
2	DPN, positive β-catenin staining	M	25	Cheek	Expectative	10 months	NP	NED	DPN
3	Classification uncertain	F	47	Back	Re-excision	11 months	NP	NED	DPN
4	Possibly BIN	M	37	Cheek	Re-excision	35 months	NP	NED	DPN
5	Epithelioid/spitzoid lesion dignity uncertain	M	15	Upper leg	Expectative	7 months	NP	NED	DPN
6	Nevus, suspect for melanoma	M	33	Lower back	Expectative	8 months	NP	NED	DPN
7	Compound or blue nevus, DPN	F	75	Upper arm	Re-excision	10 months	NP	NED	DPM
8	Epithelioid blue nevus	F	29	Calf	Re-excision	15 months	NP	NED	DPM
9	Classification uncertain	M	19	Shoulder	Re-excision	16 months	NP	NED	DPM
10	CBN, melanoma	F	26	Axilla	Re-excision	4 months	NP	NED	DPM
11	Classification uncertain	F	62	Upper arm	Re-excision	19 months	NP	NED	MDPT
12	CBN, DPN, melanoma	F	54	Upper arm	Re-excision	4 months	NP	NED	MDPT
13	Atypical DPN or melanoma	M	56	Upper leg	Re-excision	22 months	-	NED	MDPT
14	Classification uncertain	M	74	Back	Re-excision	4 months	+	Satellite and lymph node metastasis (largest deposit 8.6 mm)	MDPT
15	Atypical DPN or melanoma	F	62	Back	Re-excision	7 months	-	NED	MDPT
16	Classification uncertain	F	56	Lower leg	Re-excision	3 months	-	NED	MDPT
17	Blue nevus, nodular melanoma	M	70	Neck	Re-excision	3 months	-	NED	MDPT
18	Classification uncertain	F	57	Upper leg	Re-excision	12 months	+	Satellite and lymph node metastasis (largest deposit 0,2 mm)	MDPT
19	DPN or MELTUMP	F	29	Chest	Re-excision	9 months	NP	NED	MDPT
20	Atypical DPN, MELTUMP, melanoma	F	39	Back	Re-excision	27 months	-	NED	MDPT

BIN BAP1-inactivated nevus, CBN cellular blue nevus, DPN deep penetrating nevus, DPM deep penetrating melanocytoma, MDPT malignant deep penetrating tumor, MELTUMP melanocytic tumor of unknown malignant potential, NED no evidence of disease, SNB sentinel lymph node biopsy.

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