Fig. 1: Timeline of major events in cervical cancer screening.

A timeline illustrating some of the major events in cervical cancer screening, starting with a lack of screening in the early 1900s, to the early research leading to the discovery that a microscope could be used to detect abnormal cervical cells on smears (Pap smear/test). Then in the late 1900’s was the discovery of HPV having a role in the development of cervical cancer and FDA approval of HPV testing on Pap tests. Subsequently, there was an FDA approval of HPV vaccines and new guidelines incorporating options for primary HPV screening.