Fig. 1: Different p53 expression patterns.

A, B Strong and diffuse p53 overexpression is seen in a case of HGD. C, D This example shows complete absence of p53 staining (null pattern). The base of the squamous epithelium shows normal positive staining (internal control). E, F Wild-type pattern of p53 staining in NDBE shows scattered, faintly positive nuclei.