Fig. 2: Eosinophilic variant of chromophobe renal cell carcinoma.
From: Do we need an updated classification of oncocytic renal tumors?
A The tumor shows broad trabecular and nested architecture and it is composed exclusively of eosinophilic cells. B At higher magnification, irregular (raisinoid) nuclei can be easily appreciated with extensive perinuclear halos (clearings). C CD117 (KIT) is diffusely positive. D Cytokeratin 7 is only focally positive, in contrast to diffuse reactivity typically seen in chromophobe renal cell carcinoma. However, such a result should be carefully correlated with the morphology, which in this case supports the diagnosis of chromophobe renal cell carcinoma (eosinophilic variant).
