Fig. 2: Prototypic histomorphology and immunoprofile of study cases.
From: p53 null phenotype is a “positive result” in urothelial carcinoma in situ
H&E of large cell pleomorphic pattern urothelial carcinoma in situ (A, 200×) and paired null phenotype p53 staining in lesional cells (B, 200×). H&E of large cell pleomorphic and clinging patterns urothelial carcinoma in situ (C, 200×) and paired null phenotype p53 staining in lesional cells (D, 200×). Perhaps based on patchy weak p53 staining in admixed benign admixed urothelial cells or because of unfamiliarity of the concept of “null phenotype” p53 immunoreactivity in urothelial neoplasia, p53 staining in this case was misinterpreted as wild-type. This case showed a frameshift deletion in TP53, supporting p53 staining as aberrant.
