Fig. 3: Global genomic landscape of NSMP uterine endometrioid carcinomas.
From: Genomic landscape of endometrial carcinomas of no specific molecular profile
A Summary of broad copy number alterations in the three molecular clusters of uterine endometrioid carcinomas of no special molecular profile (NSMP-UEC) based on GISTIC results. Each column indicates a chromosomal arm as shown in the X-axis labels. The Y-axis represents G-score which considers the amplitude of the aberration as well as the frequency of its occurrence across samples. B Comparison of fraction of genome altered values across the three NSMP-EC clusters. C Comparison of tumor mutational burden (number of mutations/megabase) across the three NSMP-UEC clusters. D Bar-plots comparing the alteration frequency of 8 commonly altered genes among the three molecular clusters of NSMP-UEC. The black horizontal lines marked with a * at the top of each bar-plot represent statistically significant difference in the frequency of the altered gene among the clusters; n.s. not significant. C1, Cluster 1; C2, Cluster 2; C3, Cluster 3.
