Table 1 Summary of genomic findings in the three clusters of uterine endometrioid carcinomas of no special molecular profile (NSMP-UEC).
From: Genomic landscape of endometrial carcinomas of no specific molecular profile
Cluster 1 (n = 80) | Cluster 2 (n = 81) | Cluster 3 (n = 79) | All cases (n = 240) | P value | ||
|---|---|---|---|---|---|---|
Tumor mutation burden (mutations/ megabase) | Median | 7.00 | 5.9 | 4.4 | 6.00 | <0.0001 |
95% IQR | 6–10 | 4.4–7.9 | 2.9–5.9 | 2–12 | ||
Fraction of genome altered (%) | Median | 0.05 | 0.00 | 0.09 | 0.04 | <0.0001 |
95% IQR | 0–0.12 | 0–0.06 | 0–0.62 | 0.02–0.22 | ||
DNA ploidy | Median | 2.16 | 2.03 | 2.19 | 2.14 | 0.498 |
95% IQR | 2.00–2.35 | 2.00–2.33 | 2.00–2.48 | 2.00–2.41 | ||
Chromosome 1q total copy number | Median | 2.2 | 2.00 | 2.60 | 2.00 | <0.0001 |
95% IQR | 2–2.61 | 1.92–2 | 2–3.01 | 2–2.61 | ||
PTEN alterations | n (%) | 70 (88%) | 81 (100%) | 3 (4%) | 154 (64%) | <0.0001 |
PIK3R1 alterations | n (%) | 73 (91%) | 0 (0%) | 4 (5%) | 77 (32%) | <0.0001 |
PIK3CA alterations | n (%) | 8 (10%) | 60 (74%) | 35 (45%) | 102 (42%) | <0.0001 |
AKT1 alterations | n (%) | 2 (3%) | 0 (0%) | 13 (17%) | 15 (6%) | <0.0001 |
KRAS alterations | n (%) | 18 (21%) | 22 (28%) | 30 (38%) | 70 (29%) | 0.106 |
CTNNB1 alterations | n (%) | 35 (45%) | 28 (33%) | 23 (31%) | 86 (36%) | 0.0979 |
ARID1A alterations | n (%) | 41 (52%) | 45 (57%) | 22 (27%) | 108 (45%) | 0.0004 |
